What is MSR-seq™?

mesoRNA-seq (MSR-seq™) is a multiplex method for sequencing mesoRNAs, RNAs between 30-300 nucleotides. It leverages our patented capture hairpin oligonucleotide adapter to enable unbiased, multiplexed, on-bead sample processing, creating a comprehensive and accurate snapshot of the mesoRNA™ system, capturing all five measurements with in one shot.

Investigate all five mesoRNA measurements with a single library preparation

Sequence

mesoRNA sequence

Abundance

mesoRNA abundance

Epitranscriptomic Modifications

mesoRNA modification

Charging

tRNA charging

Fragmentation

tRNA fragmentation

Scalable Preparation

The MSR-seq™ adapter's barcode enables up to twelve samples per library, ensuring consistency and saving time.

Unbiased Profiling

Unbiased and efficient adapter ligation enables a complete and accurate picture of the mesoRNA system.

On-bead Processing

Solid state support enables a column free approach, simplifying lab flows, avoiding purification bias, reducing input requirements, and optimising for large scale automation.

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